Copper(II)-Catalyzed Asymmetric 1,3-Dipolar [3+4] Cycloaddition and Kinetic Resolution of Azomethine Imines with Azoalkenes
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- 作者：Liang Wei ; Zuo-Fei Wang ; Lu Yao ; Guofu Qiu ; Haiyan Tao ; Hua Li and Chun-Jiang Wang
- 刊名：Advanced Synthesis & Catalysis
- 出版年：2016
- 出版时间：December 22, 2016
- 年：2016
- 卷：358
- 期：24
- 页码：3955-3959
- 全文大小：1214K
- ISSN：1615-4169
文摘
An unprecedented copper(II)-catalyzed enantioselective 1,3-dipolar [3+4] cycloaddition of azomethine imines with in situ formed azoalkenes has been realized. This strategy provides a facile access to biologically important 1,2,4,5-tetrazepine derivatives in high yield with exclusive regioselectivity and high stereoselectivity. Moreover, enantioenriched azomethine imines could be obtained via an efficient kinetic resolution using the same approach.