Oxidative Divergent Bicyclizations of 1,n-Enynes through α-C(sp³)-H Functionalization of Alkyl Nitriles

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• 作者：Ming Hu ; Meng Li ; Fang-Lin Tan ; Ren-Jie Song ; Ye-Xiang Xie and Jin-Heng Li
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2017
• 出版时间：January 4, 2017
• 年：2017
• 卷：359
• 期：1
• 页码：120-129
• 全文大小：1290K
• ISSN：1615-4169

文摘

A new, radical-mediated, divergent bicyclization of 1,n-enynes by α-C(sp³)–H oxidative functionalization of alkyl nitriles is described using the Sc(OTf)₃ and Ag₂O system. The reaction allows the selective functionalization of one or two C(sp³)−H bonds α to the nitrile group by both oxidants and the substitution effect co-controlled the divergent bicyclization reactions, and offers a step- and atom-economical access to diverse polycycles with broad substrate scope and high selectivity.