Total Synthesis of the Diterpenoid (+)-Harringtonolide

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• 作者：Hai-Jun Zhang ; Dr. Lin Hu ; Dr. Zhiqiang Ma ; Dr. Ruining Li ; Zhen Zhang ; Cheng Tao ; Dr. Bin Cheng ; Dr. Yun Li ; Dr. Huifei Wang and Prof. Dr. Hongbin Zhai
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：September 12, 2016
• 年：2016
• 卷：128
• 期：38
• 页码：11810-11813
• 全文大小：871K
• ISSN：1521-3757

文摘

Described herein is the first asymmetric total synthesis of (+)-harringtonolide, a natural diterpenoid with an unusual tropone imbedded in a cagelike framework. The key transformations include an intramolecular Diels–Alder reaction and a rhodium-complex-catalyzed intramolecular [3+2] cycloaddition to install the tetracyclic core as well as a highly efficient tropone formation.