An Efficient One-pot Three-component Process for Synthesis of Perfluoroalkylated Quinolizines

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• 作者：Dandan Shen ; Yanjie Xu ; Dong He ; Jing Han ; Jie Chen ; Hongmei Deng ; Min Shao ; Hui Zhang and Weiguo Cao
• 刊名：Chinese Journal of Chemistry
• 出版年：2016
• 出版时间：May, 2016
• 年：2016
• 卷：34
• 期：5
• 页码：524-532
• 全文大小：516K
• ISSN：1614-7065

文摘

A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. Moderate yields were obtained under mild condition. The structures of perfluoroalkylated quinolizine derivatives were characterized by means of ¹H NMR, ¹³C NMR, ¹⁹F NMR, IR, LRMS and HRMS. Furthermore, the reaction mechanism was proposed.