Biomineralization of Versatile CuS/Gd₂O₃ Hybrid Nanoparticles for MR Imaging and Antitumor Photothermal Chemotherapy

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• 作者：Huai-Xin Zhao ; Hong Wang ; Quan Zou ; Dr. Shao-Kai Sun ; Prof. Chunshui Yu ; Prof. Xuejun Zhang and Dr. Yan-Yan Fu
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：September 6, 2016
• 年：2016
• 卷：11
• 期：17
• 页码：2458-2469
• 全文大小：2957K
• ISSN：1861-471X

文摘

The versatile application of nanoparticles in integrating imaging and therapy has aroused extensive research interest in precision medicine. Of the various nanoparticles that have been studied, CuS has shown great potential in the construction of multifunctional agents, owing to its excellent photothermal heating properties. Herein, we report a facile one-pot biomineralization approach for the preparation of versatile bovine-serum-albumin-conjugated CuS/Gd₂O₃ hybrid nanoparticles (BSA−CuS/Gd₂O₃ HNPs), which simultaneously possessed strong longitudinal relaxivity, an outstanding photothermal effect, high drug-loading capacity, and pH/temperature-responsive drug release. The versatile nanoparticles were used for magnetic resonance imaging (MRI) and antitumor photothermal chemotherapy, both in vitro and in vivo. In vivo MRI showed that the BSA−CuS/Gd₂O₃ HNPs had a long circulation time and effective passive tumor-uptake ability. More importantly, combined in vitro and in vivo therapy demonstrated that drug-loaded BSA−CuS/Gd₂O₃ HNPs offered outstanding synergistic therapeutic efficacy for tumor inhibition.