Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma

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• 作者：Shih-Min Hsia ; Cheng-Chia Yu ; Yin-Hua Shih ; Michael Yuanchien Chen ; Tong-Hong Wang ; Yu-Ting Huang and Tzong-Ming Shieh
• 关键词：apoptosis ; ataxia telangiectasia mutated (ATM) ; DNA damage ; isoliquiritigenin ; oral squamous cell carcinoma (OSCC)
• 刊名：Head & Neck
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：38
• 期：S1
• 页码：E360-E371
• 全文大小：6710K
• ISSN：1097-0347

文摘

Isoliquiritigenin (ISL), a natural compound extracted from licorice, has chemopreventive and antitumor activities. The purpose of this study was to investigate the anticancer effect of ISL on human oral squamous cell carcinoma (OSCC).