Palladium(0)-Catalyzed Intermolecular Carbocyclization of (1,n)-Diynes and Bromophenols: An Efficient Route to Tricyclic Scaffolds

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• 作者：Lu Bai ; Yini Yuan ; Prof. Dr. Jingjing Liu ; Jiaoyu Wu ; Lingbo Han ; Dr. Hui Wang ; Prof. Dr. Yaoyu Wang and Prof. Dr. Xinjun Luan
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：June 6, 2016
• 年：2016
• 卷：128
• 期：24
• 页码：7060-7064
• 全文大小：1077K
• ISSN：1521-3757

文摘

A novel palladium(0)-catalyzed dearomative cyclization reaction of bromophenols with (1,n)-diynes has been developed for building two new types of tricyclic architectures containing a quaternary carbon center. This method employs inexpensive bromophenols, and easily accessible tethered diynes. It exhibits a broad substrate scope and tolerates various functional groups. Preliminary results with commercially available chiral ligands indicate that enantioselective variants are feasible for both cyclization processes.