Adverse effects of incretin-based therapies on major cardiovascular and arrhythmia events: meta-analysis of randomized trials

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• 作者：Tiansheng Wang ; Fei Wang ; Junwen Zhou ; Huilin Tang and Sharon Giovenale
• 刊名：Diabetes/Metabolism Research and Reviews
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：32
• 期：8
• 页码：843-857
• 全文大小：386K
• ISSN：1520-7560

文摘

Recent cardiovascular outcome trials of incretin-based therapies (IBT) in type 2 diabetes have not demonstrated either benefit or harm in terms of major adverse cardiovascular events (MACE). Earlier meta-analyses showed conflicting results but were limited in methodology. We aimed to perform an updated meta-analysis of all available incretin therapies on the incidence of MACE plus arrhythmia and heart failure.