Differences in and correlations between cognitive abilities and brain volumes in healthy control, mild cognitive impairment, and Alzheimer disease groups

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• 作者：Soon-Cheol Chung ; Mi-Hyun Choi ; Hyung-Sik Kim ; Jung-Chul Lee ; Sung-Jun Park ; Ul-Ho Jeong ; Ji-Hye Baek ; Seon-Young Gim ; Young Chil Choi ; Beob-Yi Lee ; Dae-Woon Lim and Boseong Kim
• 关键词：cognitive ability ; brain volume ; mild cognitive impairment ; Alzheimer's disease
• 刊名：Clinical Anatomy
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：29
• 期：4
• 页码：473-480
• 全文大小：296K
• ISSN：1098-2353

文摘

The purpose of this study is to investigate differences in and correlations between cognitive abilities and brain volumes in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups. The Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), which is used to diagnose AD, was used to measure the cognitive abilities of the study subjects, and the volumes of typical brain components related to AD diagnosis—cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM)—were acquired. Of the CERAD-K subtests, the Boston Naming Test distinguished significantly among the HC, MCI, and AD groups. GM and WM volumes differed significantly among the three groups. There was a significant positive correlation between Boston Naming Test scores and GM and WM volumes. In conclusion, the Boston Naming Test and GM and WM brain volumes differentiated the three tested groups accurately, and there were strong correlations between Boston Naming Test scores and GM and WM volumes. These results will help to establish a test method that differentiates the three groups accurately and is economically feasible. Clin. Anat. 29:473–480, 2016.