Covalent Self-Assembly and One-Step Photocrosslinking of Tyrosine-Rich Oligopeptides to Form Diverse Nanostructures
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- 作者：Dr. Kyoung-Ik Min ; Dr. Gyeongwon Yun ; Dr. Yoonjung Jang ; Kyung-Rok Kim ; Dr. Young Ho Ko ; Dr. Hyung-Seok Jang ; Prof. Dr. Yoon-Sik Lee ; Prof. Dr. Kimoon Kim and Prof. Dr. Dong-Pyo Kim
- 刊名：Angewandte Chemie International Edition
- 出版年：2016
- 出版时间：June 6, 2016
- 年：2016
- 卷：55
- 期：24
- 页码：6925-6928
- 全文大小：1968K
- ISSN：1521-3773
文摘
We present covalently self-assembled peptide hollow nanocapsule and peptide lamella. These biomimetic dityrosine peptide nanostructures are synthesized by one-step photopolymerization of a tyrosine-rich short peptide without the aid of a template. This simple approach offers direct synthesis of fluorescent peptide nanocages and free-standing thin films. The simple crosslinked peptide lamella films provide robust mechanical properties with an elastic modulus of approximately 30 GPa and a hardness of 740 MPa. These nanostructures also allow for the design of peptidosomes. The approach taken here represents a rare example of covalent self-assembly of short peptides into nano-objects, which may be useful as microcompartments and separation membranes.