Haploidentical hematopoietic stem cell transplantation for a case with X-linked chronic granulomatous disease

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• 作者：Ling Zhou ; Lu-Jia Dong ; Zhi-Yong Gao ; Xin-Jian Yu and Dao-Pei Lu
• 刊名：Pediatric Transplantation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：21
• 期：1
• 全文大小：219K
• ISSN：1399-3046

文摘

CGD is a rare primary immunodeficiency with high mortality rates when treated conventionally, especially for the X-chromosome-linked form. HSCT is the only curative therapy for CGD; however, haploidentical transplantation in CGD is rare. Here, we report a case of X-linked CGD treated successfully by haploidentical HSCT. The patient showed a positive result with full donor chimerism, good quality of life, and the absence of recurrent infectious diseases at follow-up (68 months). Thus, haploidentical HSCT may serve as an acceptable treatment approach for patients who have CGD, but no HLA-matched related or unrelated donor.