In Situ Multimodality Imaging of Cancerous Cells Based on a Selective Performance of Fe²⁺-Adsorbed Zeolitic Imidazolate Framework-8

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• 作者：Tianyu Du ; Chunqiu Zhao ; Fawad ur Rehman ; Lanmei Lai ; Xiaoqi Li ; Yi Sun ; Shouhua Luo ; Hui Jiang ; Ning Gu ; Matthias Selke and Xuemei Wang
• 刊名：Advanced Functional Materials
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：27
• 期：5
• 全文大小：2151K
• ISSN：1616-3028

文摘

Metal-organic frameworks possess tremendous potential in biomedical areas for their particular structure. In this study, the authors explored Fe²⁺-adsorbed nanoscaled zeolitic imidazolate framework-8 (ZIF-8) for in vivo multimodal imaging of cancerous cells for early diagnosis of target cancers. The observations demonstrate that adding Fe²⁺ into the suspension of ZIF-8 can neutralize the alkalinity and lower toxicity, while the Fe²⁺-adsorbed ZIF-8 can readily transform to fluorescence ZnO and super paramagnetic Fe₃O₄ under the synergistic reaction of ROS, GSH, and acids. It is evident that the formation of the nanoclusters ZnO and Fe₃O₄ only occurred in cancerous cells and does not take place in normal cells, which can be attributed to the different ROS levels and specific micro-environment in tumor and normal cells. This raises the possibility for the Fe²⁺-adsorbed zeolitic imidazolate frameworks to act as promising agents for the in vivo multimodal imaging of cancers in their early stage.