Copper-Catalyzed Formal [2+2+1] Heteroannulation of Alkenes, Alkylnitriles, and Water: Method Development and Application to a Total Synthesis of (±)-Sacidumlignan D
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- 作者：Tu M. Ha ; Dr. Claire Chatalova-Sazepin ; Dr. Qian Wang and Prof. Dr. Jieping Zhu
- 刊名：Angewandte Chemie International Edition
- 出版年：2016
- 出版时间：August 1, 2016
- 年：2016
- 卷：55
- 期：32
- 页码：9249-9252
- 全文大小：731K
- ISSN：1521-3773
文摘
A copper-catalyzed three-component reaction of alkenes, alkylnitriles, and water affords γ-butyrolactones in good yields. The domino process involves an unprecedented hydroxy-cyanoalkylation of alkenes and subsequent lactonization with the creation of three chemical bonds and a quaternary carbon center. The synthetic potential of this novel [2+2+1] heteroannulation reaction was illustrated by a concise total synthesis of (±)-sacidumlignan D.