Mesenchymal stem cell-conditioned medium accelerates wound healing with fewer scars

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• 作者：Meirong Li ; Fuxin Luan ; Yali Zhao ; Haojie Hao ; Jiejie Liu ; Liang Dong ; Xiaobing Fu and Weidong Han
• 刊名：International Wound Journal
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：14
• 期：1
• 页码：64-73
• 全文大小：1480K
• ISSN：1742-481X

文摘

Mesenchymal stem cells (MSCs) derived from k?url=JVOPjkBpw10--qJdTa6mmlyjccO_6QuBgJhBj-IW3AuVxU7Jb4VtIibEZU9GY9SWk_5NDk2qvBm7laZOZGT1UhkHtOoECjsiAF4RZVMuzAm#_blank" title="Link to external resource: http://www.baidu.com/link?url=JVOPjkBpw10--qJdTa6mmlyjccO_6QuBgJhBj-IW3AuVxU7Jb4VtIibEZU9GY9SWk_5NDk2qvBm7laZOZGT1UhkHtOoECjsiAF4RZVMuzAm#_blank" target="_blank">umbilical cords (UC-MSCs) have been shown to enhance cutaneous wound healing by means of the paracrine activity. Fibroblasts are the primary cells involved in wound repair. The paracrine effects of UC-MSCs on dermal fibroblasts have not been fully explored in vitro or in vivo. Dermal fibroblasts were treated with conditioned media from UC-MSCs (UC-MSC-CM). In this model, UC-MSC-CM increased the proliferation and migration of dermal fibroblasts. Moreover, adult dermal fibroblasts transitioned into a phenotype with a low myofibroblast formation capacity, a decreased ratio of transforming growth factor-β1,3 (TGF-β1/3) and an increased ratio of matrix metalloproteinase/tissue inhibitor of metalloproteinases (MMP/TIMP). Additionally, UC-MSC-CM-treated wounds showed accelerated healing with fewer scars compared with control groups. These observations suggest that UC-MSC-CM may be a feasible strategy to promote cutaneous repair and a potential means to realise scarless healing.