Regio- and Enantioselective Cobalt-Catalyzed Sequential Hydrosilylation/Hydrogenation of Terminal Alkynes

详细信息    查看全文

• 作者：Jun Guo ; Xuzhong Shen and Prof. Zhan Lu
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：January 9, 2017
• 年：2017
• 卷：56
• 期：2
• 页码：615-618
• 全文大小：589K
• ISSN：1521-3773

文摘

A highly regio- and enantioselective cobalt-catalyzed sequential hydrosilylation/hydrogenation of alkynes was developed to afford chiral silanes. This one-pot method is operationally simple and atom economic. It makes use of relatively simple and readily available starting materials, namely alkynes, silanes, and hydrogen gas, to construct more valuable chiral silanes. Primary mechanistic studies demonstrated that highly regioselective hydrosilylation of alkynes with silanes occurred as a first step, and the subsequent cobalt-catalyzed asymmetric hydrogenation of the resulting vinylsilanes showed good enantioselectivity.