Synthesis of Novel Imidazo[1,2-a]pyridin-2-amines from Arylamines and Nitriles via Sequential Addition and I2/KI-Mediated Oxidative Cyclization
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- 作者：Xianhai Tian ; Lina Song ; Manman Wang ; Zhigang Lv ; Dr. Jie Wu ; Dr. Wenquan Yu and Prof. Dr. Junbiao Chang
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：May 23, 2016
- 年：2016
- 卷：22
- 期：22
- 页码：7617-7622
- 全文大小：712K
- ISSN：1521-3765
文摘
A novel and practical strategy for the construction of imidazo[1,2-a]pyridin-2-amine frameworks has been developed. The present sequential approach involves addition of arylamines to nitriles and I2/KI-mediated oxidative C−N bond formation without purification of the intermediate amidines. This operationally simple synthetic process provides a facile access to a variety of new 2-amino substituted imidazo[1,2-a]pyridines and related heterocyclic compounds in an efficient and scalable fashion.