Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization
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- 作者：Ertong Li ; Zhiyuan Hu ; Lina Song ; Dr. Wenquan Yu and Prof. Dr. Junbiao Chang
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：July 25, 2016
- 年：2016
- 卷：22
- 期：31
- 页码：11022-11027
- 全文大小：518K
- ISSN：1521-3765
文摘
A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclization. This transition-metal-free synthetic process is broadly applicable to a variety of aromatic, aliphatic, and α,β-unsaturated aldehydes, and can be conveniently conducted on the gram scale.