Trichomonas vaginalis induces IL-1β production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux
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- 作者：Na-Yeong Gu ; Jung-Hyun Kim ; Ik-Hwan Han ; Su-Jeong Im ; Min-Young Seo ; Yong-Hoon Chung and Jae-Sook Ryu
- 刊名：The Prostate
- 出版年：2016
- 出版时间：July 1, 2016
- 年：2016
- 卷：76
- 期：10
- 页码：885-896
- 全文大小：1121K
- ISSN：1097-0045
文摘
Trichomonas vaginalis is a sexually transmitted protozoan parasite that causes vaginitis in women, and urethritis and prostatitis in men. IL-1β is synthesized as immature pro-IL-1β, which is cleaved by activated caspase-1. Caspase-1 is, in turn, activated by a multi-protein complex known as an inflammasome. In this study, we investigated the inflammatory response of a prostate epithelial cell line (RWPE-1) to T. vaginalis and, specifically, the capacity of T. vaginalis to activate the NLRP3 inflammasome.