Cover Picture: A General and Efficient Synthesis of 2-Pyridones, 2-Quinolinones, and 1-Isoquinolinones from Azine N-Oxides (Asian J. Org. Chem. 12/2016)
详细信息 查看全文
- 作者：Prof. Dong Wang ; Junjie Zhao ; Yuxi Wang ; Jianyong Hu ; Linna Li ; Longfei Miao ; Hairong Feng ; Prof. Laurent Dé ; saubry and Prof. Peng Yu
- 刊名：Asian Journal of Organic Chemistry
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：5
- 期：12
- 页码：1411
- 全文大小：340K
- ISSN：2193-5815
文摘
Hydroxyl N-heteroarenes, which remain challenging to synthesize via current methods, are present in numerous natural products and are ubiquitous building blocks in medicinal chemistry. A novel, general and practical approach for the synthesis of hydroxyl N-heteroarenes from the corresponding N-oxide precursors has been established. This method employs bromotripyrrolidinophosphonium hexafluorophosphate (PyBrop) as an activating agent and sodium acetate/water as the base/nucleophile combination. The mechanism of the reaction has been elucidated by isotopic labeling experiments. More information can be found in the Communication by Dong Wang, Peng Yu et al. on page 1442 in Issue 12, 2016 (DOI: 10.1002/ajoc.201600430).