The sphingosine-1-phosphate receptor 1 binding molecule FTY720 inhibits osteoclast formation in rats with ligature-induced periodontitis
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- 作者：D.-E. Lee ; J.-H. Kim ; S.-H. Choi ; J.-H. Cha ; E.-J. Bak and Y.-J. Yoo
- 刊名：Journal of Periodontal Research
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：52
- 期：1
- 页码：33-41
- 全文大小：1126K
- ISSN：1600-0765
文摘
Osteoclast precursors (OPs) re-migrate from the bone surface into blood vessels through sphingosine-1-phosphate receptor 1 (S1PR1) expression. T cells also express S1PR1, mediating their migration from the lymph nodes into blood vessels. OP and T-cell migration are one of the sequential steps related to osteoclast formation. To characterize the role of S1PR1 in osteoclast formation induced by periodontitis, we investigated the effect of S1PR1-binding molecule FTY720 (FTY) on the number of OPs and T cells in periodontal tissue and peripheral blood of rats with ligature-induced periodontitis.