The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1 accumulation and fibrosis in hypoxic adipose tissue

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• 作者：Xiaole Li ; Jia Li ; Lulu Wang ; Aiyun Li ; Zhixia Qiu ; Lian-wen Qi ; Junping Kou ; Kang Liu ; Baolin Liu and Fang Huang
• 刊名：British Journal of Pharmacology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：173
• 期：12
• 页码：2001-2015
• 全文大小：3612K
• ISSN：1476-5381

文摘

Hypoxic activation of hypoxia-inducible factor 1α (HIF-1α) and fibrosis in adipose tissue contribute to adipose dysfunction. This study was designed to investigate the effects of metformin and resveratrol on the regulation of HIF-1α and fibrosis in hypoxic adipose tissue.