An Unexpected Potassium Iodide-Promoted Nucleophilic Substitution Reaction between 2-Acyloxy-2H-azirines and Carboxylic Acids
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- 作者：Xiyan Duan ; Kun Yang ; Jianwei Liu ; Xianglei Kong ; Ju Liang ; Dongju Zhou ; Huiyun Zhou ; Yanping Zhang ; Ning Liu ; Shuxiao Feng ; Guangna Gu ; Jun Lu ; Nazi Song ; Dongliang Zhang and Junying Ma
- 刊名：Advanced Synthesis & Catalysis
- 出版年：2016
- 出版时间：October 20, 2016
- 年：2016
- 卷：358
- 期：20
- 页码：3161-3166
- 全文大小：490K
- ISSN：1615-4169
文摘
The acyloxy group of 2-acyloxy-2H-azirines has been displaced by carboxylic acids to generate the corresponding 2-acyloxy-2H-azirines by using potassium iodide as a promotor. This metal-free method can be performed with a wide scope of substrates readily generating products in moderate to high yields. It also represents an example of nucleophilic substitution between esters and carboxylic acids under metal-free reaction conditions for the first time.