DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs
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- 作者：Prof. Richard A. Lerner and Prof. Dr. Sydney Brenner
- 刊名：Angewandte Chemie International Edition
- 出版年：2017
- 出版时间：January 24, 2017
- 年：2017
- 卷：56
- 期：5
- 页码：1164-1165
- 全文大小：665K
- ISSN：1521-3773
文摘
“… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow scientists to do selections on the benchtop that previously required access to large and complex high-throughput screening centers …” Read more in the Guest Editorial by Richard A. Lerner and Sydney Brenner.