The critical role of mast cell-derived hypoxia-inducible factor-1α in regulating mast cell function

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• 作者：Xin Liang ; Guifang Yin ; Yuanyuan Ma ; Ke Xu ; Jianwen Liu and Jiyu Li
• 刊名：Journal of Pharmacy and Pharmacology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：68
• 期：11
• 页码：1409-1416
• 全文大小：912K
• ISSN：2042-7158

文摘

During colorectal tumour progression, the tumour microenvironment becomes hypoxic, and infiltration of a large number of inflammatory cells occurs. The mast cells (MCs) are a type of immune cells plays an important role in tumour angiogenesis. However, it is unclear whether the role of MC in colorectal cancer is to promote or to inhibit tumour growth.