Assembly of Enantioenriched cis-3a,8a-Hexahydropyrrolo[2,3-b]indole Scaffolds by Silver(I)-Catalyzed Asymmetric Domino Reaction of Isocyanoacetates in the Presence of Cinchona-Derived Chiral Phosphorus Ligands
文摘
By using Cinchona-derived chiral phosphines as catalytic ligands, enantioenriched cis-3a,8a-hexahydropyrrolo[2,3-b]indoles (ent-HPIs), which are core scaffolds in a large array of biologically active natural products, can be convergently assembled under mild conditions through the silver(I)-catalyzed asymmetric domino reaction of readily available isocyanoacetates and 2-(2-aminophenyl)acrylates. Various functionalities can be tolerated in the reaction, affording enantioenriched HPIs in high overall yields and good enantioselectivities (up to 92% ees).