Copper-Catalyzed Bromination of C(spp>3p>)−H Bonds Distal to Functional Groups

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• 作者：Tao Liu ; Dr. Michael C. Myers and Prof. Dr. Jin-Quan Yu
• 刊名：Angewandte Chemie
• 出版年：2017
• 出版时间：January 2, 2017
• 年：2017
• 卷：129
• 期：1
• 页码：312-315
• 全文大小：684K
• ISSN：1521-3757

文摘

Selective bromination of γ-methylene C(spp>3p>)−H bonds of aliphatic amides and δ-methylene C(spp>3p>)−H bonds of nosyl-protected alkyl amines are developed using NBS as the brominating reagent and catalytic amount of Cup>IIp>/phenanthroline complexes as the catalyst. Aryl and benzylic C−H bonds at other locations remain intact during this directed radical abstraction reaction.