The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker
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- 作者：Lijuan Xiao ; Rainer B. Lanz ; Anna Frolov ; Patricia D. Castro ; Zheng Zhang ; Baijun Dong ; Wei Xue ; Sung Yun Jung ; John P. Lydon ; Dean P. Edwards ; Michael A. Mancini ; Qin Feng ; Michael M. Ittmann and Bin He
- 刊名：The Prostate
- 出版年：2016
- 出版时间：October 1, 2016
- 年：2016
- 卷：76
- 期：14
- 页码：1271-1284
- 全文大小：4095K
- ISSN：1097-0045
文摘
TMPRSS2-ERG fusion occurs in about half of prostate cancers and results in over-expression of the oncogenic ERG protein in the prostate. The mechanism by which ERG contributes to prostate cancer initiation and progression remains largely unknown. Because ERG is a transcriptional activator, we reasoned that the target genes regulated by ERG could contribute to prostate cancer development.