Detection of lymph node metastases in pediatric and adolescent/young adult sarcoma: Sentinel lymph node biopsy versus fludeoxyglucose positron emission tomography imaging—A prospective trial
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- 作者：Lars M. Wagner ; Nathalie Kremer ; Michael J. Gelfand ; Susan E. Sharp ; Brian K. Turpin ; Rajaram Nagarajan ; Gregory M. Tiao ; Joseph G. Pressey ; Julie Yin and Roshni Dasgupta
- 刊名：Cancer
- 出版年：2017
- 出版时间：January 1, 2017
- 年：2017
- 卷：123
- 期：1
- 页码：155-160
- 全文大小：210K
- ISSN：1097-0142
文摘
Lymph node metastases are an important cause of treatment failure for pediatric and adolescent/young adult (AYA) sarcoma patients. Nodal sampling is recommended for certain sarcoma subtypes that have a predilection for lymphatic spread. Sentinel lymph node biopsy (SLNB) may improve the diagnostic yield of nodal sampling, particularly when single-photon emission computed tomography/computed tomography (SPECT-CT) is used to facilitate anatomic localization. Functional imaging with positron emission tomography/computed tomography (PET-CT) is increasingly used for sarcoma staging and is a less invasive alternative to SLNB. To assess the utility of these 2 staging methods, this study prospectively compared SLNB plus SPECT-CT with PET-CT for the identification of nodal metastases in pediatric and AYA patients.