Advances in Asymmetric Diastereodivergent Catalysis

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• 作者：Manisha Bihani and John C.-G. Zhao
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2017
• 出版时间：February 20, 2017
• 年：2017
• 卷：359
• 期：4
• 页码：534-575
• 全文大小：12443K
• ISSN：1615-4169

文摘

Because the biological and/or pharmacological properties of a given molecule often depend on the absolute and relative configurations of the stereogenic centers, different diastereomers may exhibit totally different biological and/or pharmacological activities. Therefore, for compounds containing multiple stereogenic centers, the stereoselective asymmetric synthesis of all of the individual diastereomers, preferably using a catalytic method, is of great interest and importance in organic synthesis and drug discovery. In this context, the development of catalytic diastereodivergent methods is highly desirable, since it provides one of the most efficient ways to access multiple diastereomers from the same substrates. The current review attempts to summarize the developments in the field of asymmetric diastereodivergent catalysis.