Cytologic Differential Diagnosis of Malignant Mesothelioma and Reactive Mesothelial Cells With FISH Analysis of p16
详细信息 查看全文
- 作者：Kenzo Hiroshima ; Di Wu ; Mizue Hasegawa ; Eitetsu Koh ; Yasuo Sekine ; Daisuke Ozaki ; Toshikazu Yusa ; Ann E. Walts ; Alberto M. Marchevsky ; Kazuki Nabeshima ; Yuji Tada ; Hideaki Shimada and Masatoshi Tagawa
- 刊名：Diagnostic Cytopathology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：44
- 期：7
- 页码：591-598
- 全文大小：584K
- ISSN：1097-0339
文摘
Mesothelioma patients often present with serosal effusions, which are ideal for cytopathological diagnoses. However, the morphological overlap between malignant and benign mesothelial proliferation can make a conclusive cytological diagnosis of mesothelioma elusive because immunohistochemical staining does not discriminate definitively between the two in this setting. p16 is deleted in up to 80% of pleural mesotheliomas. The aim of this study was to establish the correlation between the p16 deletion status of the cell block with that of its corresponding tumor using fluorescence in situ hybridization (FISH) analysis for individual patient tumors.