Decrease in somatostatin-positive cell density in the amygdala of females with major depression

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• 作者：Gaelle Douillard-Guilloux ; David Lewis ; Marianne L. Seney and Etienne Sibille
• 刊名：Depression and Anxiety
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：34
• 期：1
• 页码：68-78
• 全文大小：937K
• ISSN：1520-6394

文摘

Somatostatin (SST) is a neuropeptide expressed in a subtype of gamma-aminobutyric acid (GABA) interneurons that target the dendrites of pyramidal neurons. We previously reported reduced levels of SST gene and protein expression in the postmortem amygdala of subjects with major depressive disorder (MDD). This reduction was specific to female subjects with MDD.