“Helix-in-Helix” Superstructure Formation through Encapsulation of Fullerene-Bound Helical Peptides within a Helical Poly(methyl methacrylate) Cavity

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• 作者：Dr. Naoki Ousaka ; Fumihiko Mamiya ; Yoshiaki Iwata ; Dr. Katsuyuki Nishimura and Prof. Dr. Eiji Yashima
• 刊名：Angewandte Chemie
• 出版年：2017
• 出版时间：January 16, 2017
• 年：2017
• 卷：129
• 期：3
• 页码：809-813
• 全文大小：1545K
• ISSN：1521-3757

文摘

A one-handed 3₁₀-helical hexapeptide is efficiently encapsulated within the helical cavity of st-PMMA when a fullerene (C₆₀) derivative is introduced at the C-terminal end of the peptide. The encapsulation is accompanied by induction of a preferred-handed helical conformation in the st-PMMA backbone with the same-handedness as that of the hexapeptide to form a crystalline st-PMMA/peptide-C₆₀ inclusion complex with a unique optically active helix-in-helix structure. Although the st-PMMA is unable to encapsulate the 3₁₀-helical peptide without the terminal C₆₀ unit, the helical hollow space of the st-PMMA is almost filled by the C₆₀-bound peptides. This result suggests that the C₆₀ moiety can serve as a versatile molecular carrier of specific molecules and polymers in the helical cavity of the st-PMMA for the formation of an inclusion complex, thus producing unique supramolecular soft materials that cannot be prepared by other methods.