High-Content Screening Identifies Src Family Kinases as Potential Regulators of AR-V7 Expression and Androgen-Independent Cell Growth

详细信息    查看全文

• 作者：Adam T. Szafran ; Cliff Stephan ; Michael Bolt ; Maureen G. Mancini ; Marco Marcelli and Michael A. Mancini
• 刊名：The Prostate
• 出版年：2017
• 出版时间：January 1, 2017
• 年：2017
• 卷：77
• 期：1
• 页码：82-93
• 全文大小：2828K
• ISSN：1097-0045

文摘

AR-V7 is an androgen receptor (AR) splice variant that lacks the ligand-binding domain and is isolated from prostate cancer cell lines. Increased expression of AR-V7 is associated with the transition from hormone-sensitive prostate cancer to more advanced castration-resistant prostate cancer (CRPC). Due to the loss of the ligand-binding domain, AR-V7 is not responsive to traditional AR-targeted therapies, and the mechanisms that regulate AR-V7 are still incompletely understood. Therefore, we aimed to explore existing classes of small molecules that may regulate AR-V7 expression and intracellular localization and their potential therapeutic role in CRPC.