Frontispiece: Visible-Light-Mediated Two-Fold Unsymmetrical C(sp³)−H Functionalization and Double C−F Substitution

详细信息    查看全文

• 作者：Linyong Li ; Dr. Tiebo Xiao ; Haoguo Chen and Prof. Lei Zhou
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：February 16, 2017
• 年：2017
• 卷：23
• 期：10
• 全文大小：1229K
• ISSN：1521-3765

文摘

Photoredox Catalysis A visible light-mediated [3+3] annulation of tertiary amines with α-trifluoromethyl alkenes was developed. The reaction offers a direct route to fluorinated tetrahydropyridines and azabicyclo[3.m.1] frameworks under very mild conditions. This protocol presents a rare example of dual sp³ C−H functionalization of tertiary amines with the formation of two different C−C bonds (one sp³−sp³ bond, one sp²−sp³ bond). Moreover, two consecutive C−F substitutions in a trifluoromethyl group were achieved in one-pot using visible light photoredox catalysis, which enables an unprecedented ring construction. More information can be found in the Communication by L. Zhou et al. on page 2249 ff.