Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis
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- 作者：Narges Sharifat ; Ghorban Mohammad Zadeh ; Mohammad-Ali Ghaffari ; Parisa Dayati ; Danielle Kamato ; Peter J. Little and Hossein Babaahmadi-Rezaei
- 刊名：Journal of Pharmacy and Pharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：69
- 期：1
- 页码：66-72
- 全文大小：590K
- ISSN：2042-7158
文摘
G protein-coupled receptor (GPCR) agonists through their receptors can transactivate protein tyrosine kinase receptors such as epidermal growth factor receptor and serine/threonine kinase receptors most notably transforming growth factor (TGF)-β receptor (TβRI). This signalling mechanism represents a major expansion in the cellular outcomes attributable to GPCR signalling. This study addressed the role and mechanisms involved in GPCR agonist, endothelin-1 (ET-1)-mediated transactivation of the TβRI in bovine aortic endothelial cells (BAECs).