AAZTA: An Ideal Chelating Agent for the Development of ⁴⁴Sc PET Imaging Agents

详细信息    查看全文

• 作者：Gá ; bor Nagy ; Dr. Dezső Szikra ; Dr. Gyö ; rgy Trencsé ; nyi ; Dr. Anikó ; Fekete ; Dr. Ildikó ; Garai ; Dr. Arianna M. Giani ; Dr. Roberto Negri ; Prof. Norberto Masciocchi ; Dr. Alessandro Maiocchi ; Dr. Fulvio Uggeri ; Prof. Imre Tó ; th ; Prof. Silvio Aime ; Prof. Giovanni B. Giovenzana and Dr. Zsolt Baranyai
• 刊名：Angewandte Chemie
• 出版年：2017
• 出版时间：February 13, 2017
• 年：2017
• 卷：129
• 期：8
• 页码：2150-2154
• 全文大小：1343K
• ISSN：1521-3757

文摘

Unprecedented fast and efficient complexation of Sc^III was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the ⁴⁴Sc(AAZTA)⁻ chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.