Translational treatment paradigm for managing non-unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic therapy
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- 作者：Alexis Donneys ; Jordan T. Blough ; Noah S. Nelson ; Joseph E. Perosky ; Sagar S. Deshpande ; Stephen Y. Kang ; Peter A. Felice ; Christian Figueredo ; Jonathan R. Peterson ; Kenneth M. Kozloff ; Benjamin Levi ; Douglas B. Chepeha and Steven R. Buchman
- 关键词：radiotherapy ; osteoradionecrosis ; pathologic fracture ; adipose-derived stromal cell ; deferoxamine
- 刊名：Head & Neck
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：38
- 期：S1
- 页码：E837-E843
- 全文大小：973K
- ISSN：1097-0347
文摘
Bony non-unions arising in the aftermath of collateral radiation injury are commonly managed with vascularized free tissue transfers. Unfortunately, these procedures are invasive and fraught with attendant morbidities. This study investigated a novel, alternative treatment paradigm utilizing adipose-derived stem cells (ASCs) combined with angiogenic deferoxamine (DFO) in the rat mandible.