Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus

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• 作者：Eric G. Vajda ; Douglas Logan ; Kenneth Lasseter ; Danielle Armas ; Diane J. Plotkin ; JD Pipkin ; Yong-Xi Li ; Rong Zhou ; David Klein ; Xiaoxiong Wei ; Stacy Dilzer ; Lin Zhi and Keith B. Marschke
• 刊名：Diabetes, Obesity and Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 页码：24-32
• 全文大小：1079K
• ISSN：1463-1326

文摘

To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of a novel, oral glucagon receptor antagonist, LGD-6972, in healthy subjects and subjects with type 2 diabetes (T2DM).