Solvent-Free Pot-, Atom- and Step-Economic Synthesis of Novel Benzo[d]thiazole-[1,3]-thiazine Hybrids in a One-Pot Reaction

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• 作者：Preeti Wadhwa ; Dr. Tanpreet Kaur and Dr. Anuj Sharma
• 刊名：Asian Journal of Organic Chemistry
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：5
• 期：6
• 页码：763-769
• 全文大小：1133K
• ISSN：2193-5815

文摘

The first catalyst- and solvent-free synthesis of novel benzo[d]thiazole-[1,3]-thiazine hybrids from benzo[d]thiazol-2-amines, isothiocyanates and dialkyl acetylenedicarboxylates with no more than 30 min of microwave irradiation is described. Moreover, the proposed strategy involves neither tedious workup nor column purification steps. This approach provides a diversity-oriented route for the rapid assembly of benzo[d]thiazole-[1,3]-thiazine frameworks. Furthermore, the methodology has excellent green credentials, scoring well in a number of green metrics, hence showing this approach to be an ideal green and sustainable process.