Efficient Purification and Release of Circulating Tumor Cells by Synergistic Effect of Biomarker and SiO2@Gel-Microbead-Based Size Difference Amplification
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- 作者：Qinqin Huang ; Bo Cai ; Bolei Chen ; Lang Rao ; Zhaobo He ; Rongxiang He ; Feng Guo ; Libo Zhao ; Kiran Kumar Kondamareddy ; Wei Liu ; Shishang Guo and Xing-Zhong Zhao
- 刊名：Advanced Healthcare Materials
- 出版年：2016
- 出版时间：July 6, 2016
- 年：2016
- 卷：5
- 期：13
- 页码：1554-1559
- 全文大小：1372K
- ISSN：2192-2659
文摘
Microfluidics-based circulating tumor cell (CTC) isolation is achieved by using gelatin-coated silica microbeads conjugated to CTC-specific antibodies. Bead-binding selectively enlarges target cell size, providing efficient high-purity capture. CTCs captured can be further released non-invasively. This stratagem enables high-performance CTC isolation for subsequent studies.