Secreted P-glycoprotein is a noninvasive biomarker of chronic rhinosinusitis

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• 作者：Angela L. Nocera ; Ana T. Meurer ; Marcel M. Miyake ; Peter M. Sadow ; Xue Han and Benjamin S. Bleier
• 刊名：The Laryngoscope
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：127
• 期：1
• 页码：E1-E4
• 全文大小：170K
• ISSN：1531-4995

文摘

The discovery of noninvasive biomarkers of chronic rhinosinusitis (CRS) is critical to enable our ability to provide prognostic information and targeted medical therapy. Epithelial P-glycoprotein (P-gp) is overexpressed in CRS and exists in an extracellular, secreted form. The objective of this study was to determine whether secreted P-gp concentrations are elevated in CRS and can be used to predict disease severity.