High-dose methylprednisolone and endothelial glycocalyx in paediatric heart surgery

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• 作者：E. Pesonen ; J. Keski-Nisula ; S. Andersson ; R. Palo ; J. Salminen and P. K. Suominen
• 刊名：Acta Anaesthesiologica Scandinavica
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：60
• 期：10
• 页码：1386-1394
• 全文大小：175K
• ISSN：1399-6576

文摘

Corticosteroids are used in paediatric heart surgery to attenuate systemic inflammatory response. Glycocalyx regulates vascular permeability, shear stress and cell adhesion on the endothelium. Syndecan-1 serves as a biomarker of glycocalyx degradation. Hydrocortisone decreased endothelial glycocalyx degradation in an experimental model. Our hypothesis was that high-dose methylprednisolone decreases glycocalyx degradation as measured by plasma sydecan-1 concentration in children undergoing cardiac surgery.