Clinical relevance of cyclooxygenase 2 and peroxisome proliferator-activated receptor in eyelid sebaceous gland carcinoma
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- 作者：Perumal Jayaraj ; Seema Sen ; Tanaya Bhattacharya ; Juhi Arora ; Sameeksha Yadav ; Varsha Chhoker ; Abhishek Kumar ; Pakitapillil S Dhanaraj ; Kameshwar S. Yadavilli and Mansi Verma
- 刊名：Histopathology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：69
- 期：2
- 页码：268-275
- 全文大小：903K
- ISSN：1365-2559
文摘
Sebaceous gland carcinoma (SGC) is a malignancy associated with the pilosebaceous unit, and occurs at ocular or non-ocular sites. Cyclooxygenases (COXs) are enzymes that are crucial for lipid metabolism. COX-2 is overexpressed in various cancers, and its inhibition by non-steroidal anti-inflammatory drugs is known to reduce the risk of many cancers. Peroxisome proliferator-activated receptor (PPAR)-γ is a transcription factor involved in adipogenesis. PPAR-γ is a potential therapeutic target for the treatment of malignant tumours, including colon carcinoma. The aim of this study was to explore the status of COX-2 and PPAR-γ as prognostic markers in human eyelid SGC.