ChemInform Abstract: An Exclusively trans-Selective Chlorocarbamoylation of Alkynes Enabled by a Palladium/Phosphaadamantane Catalyst.

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• 作者：Christine M. Le ; Xiao Hou ; Theresa Sperger ; Franziska Schoenebeck and Mark Lautens
• 关键词：indole derivatives ; isoindole derivatives ; organo-silicon compounds ; e/z-selectivity (incl. e/z-isomerism) ; catalysis ; phase-transfer catalysis ; ring closure reactions ; annulation reactions ; Editors' Choice
• 刊名：ChemInform
• 出版年：2016
• 出版时间：March, 2016
• 年：2016
• 卷：47
• 期：12
• 全文大小：29K
• ISSN：1522-2667

文摘

For the first time, a highly efficient transition-metal-catalyzed atom-economic chlorocarbamoylation reaction is reported to give access to pharmaceutically relevant methylene oxindoles, which are all obtained with E:Z selectivities <99:1.