Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction
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- 作者：Hee Jung Lee ; Seong Rak Seo ; Moon Soo Yoon ; Ji-Ye Song ; Eun Young Lee and Sang Eun Lee
- 关键词：aging ; hyaluronan ; hyaluronan synthase ; CD44 ; radiofrequency ; PCNA ; filaggrin
- 刊名：Lasers in Surgery and Medicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：48
- 期：2
- 页码：140-149
- 全文大小：8628K
- ISSN：1096-9101
文摘
Skin aging results in physiological alterations in keratinocyte activities and epidermal function, as well as dermal changes. Yet, the cellular and molecular mechanisms that cause epidermal dysfunction during skin aging are not well understood. Recently, the role of epidermal hyaluronan (HA) as an active regulator of dynamic cellular processes is getting attention and alterations in HA metabolism are thought to be important in age-related epidermal dysfunction. Microneedle fractional radiofrequency (RF) has shown effects for improving cutaneous aging. However, little is known about the effects of fractional RF on the epidermal HA and epidermal function. We investigated the effect of microneedle fractional RF on the expression of epidermal HA in young and aged mice epidermis.