Synthesis of Chiral Vicinal Diamines by Silver(I)-Catalyzed Enantioselective Aminolysis of N-Tosylaziridines

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• 作者：Prof. Dr. Zhuo Chai ; Pei-Jun Yang ; Hu Zhang ; Prof. Dr. Shaowu Wang and Prof. Dr. Gaosheng Yang
• 刊名：Angewandte Chemie International Edition
• 出版年：2017
• 出版时间：January 9, 2017
• 年：2017
• 卷：56
• 期：2
• 页码：650-654
• 全文大小：637K
• ISSN：1521-3773

文摘

The kinetic resolution of 2-aryl-N-tosylaziridines and the asymmetric desymmetrization of meso-N-tosylaziridines by ring openings with various primary and secondary anilines, and aliphatic amines as nucleophile have been realized by using a single silver(I)/chiral diphosphine complex as catalyst for the first time. The simple starting materials, broad scope, and easy scalability render this protocol a practical way to chiral vicinal diamine derivatives.