Preparation of ALA-loaded PLGA nanoparticles and its application in PDT treatment
详细信息 查看全文
- 作者：Yanping Guan ; Yi Zhou ; Jie Sheng ; Zhong Ying Jiang ; Halydan Jumahan and Yong Hu
- 关键词：coaxial electrospray ; 5-aminolevulinic acid ; nanoparticles ; photodynamic therapy ; PpIX ; PLGA
- 刊名：Journal of Chemical Technology & Biotechnology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：91
- 期：4
- 页码：1128-1135
- 全文大小：812K
- ISSN：1097-4660
文摘
Coaxial electrospray is an emerging technology to produce multilayer micro- and nano-particles (NPs) with well controlled shape and size. ALA-PDT is a fascinating technology used in the treatment for skin and other cancers. In this work, ALA-loaded poly(lactide-co-glycolide) (PLGA) (PLGA-ALA) NPs with high drug loading efficiency were produced via coaxial electrospray and used for the PDT treatment in HSC-3 cells.