Enantioselective Dearomative [3+2] Cycloaddition Reactions of Benzothiazoles
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- 作者：Dr. Dong-Chao Wang ; Dr. Ming-Sheng Xie ; Prof. Dr. Hai-Ming Guo ; Prof. Gui-Rong Qu ; Meng-Cheng Zhang and Prof. Dr. Shu-Li You
- 刊名：Angewandte Chemie International Edition
- 出版年：2016
- 出版时间：November 2, 2016
- 年：2016
- 卷：55
- 期：45
- 页码：14111-14115
- 全文大小：721K
- ISSN：1521-3773
文摘
A highly enantioselective dearomative [3+2] cycloaddition of benzothiazole has been successfully developed. A wide range of benzothiazoles and cyclopropane-1,1-dicarboxylates are suitable substrates for this reaction. The desired hydropyrrolo[2,1-b]thiazole compounds were obtained in excellent enantioselectivity and yields (up to 97 % ee and 97 % yield). With the same catalytic system, a highly efficient kinetic resolution of 2-substituted cyclopropane-1,1-dicarboxylates was also realized.