Tumor necrosis factor-α regulates interleukin-33 expression through extracellular signal-regulated kinase, p38, and nuclear factor-κB pathways in airway epithelial cells
详细信息 查看全文
- 作者：Il-Ho Park ; Joo-Hoo Park ; Jae-Min Shin and Heung-Man Lee
- 刊名：International Forum of Allergy & Rhinology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：6
- 期：9
- 页码：973-980
- 全文大小：744K
- ISSN：2042-6984
文摘
Interleukin (IL)-33 plays an important role in controlling immune responses in barrier tissues, and is a potent mediator of inflammatory diseases such as asthma, rheumatoid disease, and chronic rhinosinusitis. The aims of the present study were 2-fold: (1) to determine the stimulatory effect of tumor necrosis factor-α (TNF-α) on IL-33 production in nasal epithelial and A549 cells; and (2) to identify downstream pathways that activate IL-33 production.