Identification of Cyclin-Dependent Kinase 1 as a Novel Regulator of Type I Interferon Signaling in Systemic Lupus Erythematosus
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- 作者：Lingling Wu ; Yuting Qin ; Shiwei Xia ; Min Dai ; Xiao Han ; Yanfang Wu ; Xiaoyan Zhang ; Jianyang Ma ; Yan Wang ; Yuanjia Tang ; Zheng Liu ; Wei Zhu ; Bahija Jallal ; Yihong Yao ; Bo Qu and Nan Shen
- 刊名：Arthritis & Rheumatism
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：68
- 期：5
- 页码：1222-1232
- 全文大小：474K
- ISSN：1529-0131
文摘
Type I interferon (IFN) signaling is regarded as a central pathogenic pathway in systemic lupus erythematosus (SLE). Specific inhibition of this pathway is a core area for the development of new therapies for SLE. This study was undertaken to clarify the pathogenic mechanism involved and to identify new therapeutic targets, using a high-throughput screening platform to determine novel regulators that contribute to the overactivation of the type I IFN signaling pathway in SLE.